Objective:Malignant mucosal melanomas of the head and neck comprise a very small portion of all melanomas, particularly in the oral cavity.These lesions are associated with high rates of local recurrence, distant metastasis, and a very poor 5-year survival rate; however, the clinical outcomes of mucosal melanoma in situ of the oral cavity are unclear.Therefore, we present a case report of mucosal melanoma in situ and quad port fittings a systematic review of the literature to shed light on this rare but important disease.Methods:PubMed, Scopus, and CINAHL were searched per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Studies were only considered for inclusion if they described oral cavity melanoma in situ and documented specific data pertaining to treatment including modality, lesion size, or outcomes.Results:A total of 28 reported cases from the literature fulfilled the inclusion criteria, as well as one case from our own institution.Men comprised the majority (64.3%) of the cases, and the average age at presentation was 57.
4 years.The hard palate was the most common location, and most cases were treated with surgical excision.Eight had no evidence of disease after a minimum of six months of follow-up, one reported spread to the cervical lymph nodes, and only one reported progression with distant metastasis.Conclusion:Oral mucosal melanoma in situ is a rare entity under armour 1364182 and most commonly treated with surgical excision.
High rates of recurrence necessitate long term follow-up.Further studies may be useful to determine whether adjuvant therapy may play a role in reducing recurrence.